Mechanism of Amyloid Fibril Formation
SCIENTIFIC ILLUSTRATION PROJECT
Alzheimer’s Disease is a devastating neurological disorder that afflicts a growing geriatric population. Currently, no cure is available, but research has shown that AD neurodegeneration is linked to the formation of plaques formed by amyloid-beta oligomers and fibrils. Each of these components can interact with the neuronal membrane and promote neurotoxicity.
A schematic was drawn to show the amyloid hypothesis, where amyloid originates and how it is cleaved to form fibrils and eventually plaques. This work was published in a review article entitled “Atomic Force Microscopy to Study Molecular Mechanisms of Amyloid Fibril Formation and Toxicity in Alzheimer’s Disease” in Drug Metabolism Reviews. It can be viewed here.
Citation: Drolle E, Hane F, Lee B, Leonenko Z. 2014. Atomic Force Microscopy to Study Molecular Mechanisms of Amyloid Fibril Formation and Toxicity in Alzheimer’s Disease. Drug Metabolism Reviews, 46(2): 207-223. doi: 10.3109/03602532.2014.882354.