Atomic Force Spectroscopy Binding and Dissociation

Atomic force microscopy (AFM) is a useful technique that gives us the power to image nanoscale structures by measuring surface topography. Due to its wide range of applications, different accessories have been developed to obtain additional information regarding these structures. One of these spin-offs is called atomic force spectroscopy (AFS), which measures surface forces by taking force curves.

A schematic was drawn to describe how AFS can be used to mechanically induce the binding and dissociation of amyloid peptides. This schematic was published in a research article entitled “Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer’s Amyloid-β Peptides” in PLoS One. This paper can be found here.

Citation: Hane FT, Hayes R, Lee BY, Leonenko Z. 2016. Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer’s Amyloid-β Peptides. PLoS One, 11(1): e0147488. doi: 10.1371/journal.pone.0147488